Fumatinic

Pronunciation: FER-us FUE-ma-rate/VYE-ta-min B
Generic Name: Ferrous Fumarate/Vitamin C/Vitamin B12
Brand Name: Fumatinic

Accidental overdose of products that contain iron is a leading cause of fatal poisoning in children younger than 6 years. Keep this and all medicines out of the reach of children. In case of accidental ingestion, call the poison control center or a doctor at once.

Fumatinic is used for:

Preventing and treating certain types of anemia (eg, caused by low blood iron levels, poor nutrition). It may also be used for other conditions as determined by your doctor.

Fumatinic is a vitamin and iron combination. It works by providing vitamins and iron to the body.

Do NOT use Fumatinic if:

• you are allergic to any ingredient in Fumatinic


• you have certain iron metabolism problems (eg, hemosiderosis, hemochromatosis) or high levels of iron in your blood

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fumatinic:

Some medical conditions may interact with Fumatinic. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have pernicious anemia or a history of other blood problems (eg, hemolytic anemia, porphyria, thalassemia)


• if you have a peptic ulcer or bowel problems (eg, colitis, Crohn disease, diverticulitis)


• if you have had multiple blood transfusions

Some MEDICINES MAY INTERACT with Fumatinic. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Chloramphenicol because it may decrease Fumatinic's effectiveness


• Fluorouracil because the risk of its side effects may be increased by Fumatinic


• Doxycycline, hydantoins (eg, phenytoin), penicillamine, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Fumatinic

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fumatinic may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fumatinic:

Use Fumatinic as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Fumatinic by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you also take an antacid, a bisphosphonate (eg, alendronate), cefdinir, eltrombopag, methyldopa, penicillamine, a quinolone antibiotic (eg, ciprofloxacin), or a tetracycline (eg, doxycycline, minocycline), ask your doctor or pharmacist how to take it with Fumatinic.


• If you miss a dose of Fumatinic, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fumatinic.

Important safety information:

• Do NOT take more than the recommended dose without checking with your doctor.


• Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Fumatinic unless your doctor tells you to.


• Fumatinic has iron, vitamin C, and vitamin B₁₂ in it. Before you start any new medicine, check the label to see if it also has iron, vitamin C, or vitamin B₁₂ in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Fumatinic has iron in it. Iron overdose is a leading cause of fatal poisoning in children younger than 6 years. In case of an overdose, call a doctor or poison control center right away.


• Fumatinic may darken the stools. This is normal and not a cause for concern.


• Fumatinic may interfere with certain lab tests, including tests used to check for blood in the stool. Be sure your doctor and lab personnel know you are taking Fumatinic.


• Lab tests, including hematocrit, hemoglobin levels, and blood iron levels, may be performed while you use Fumatinic. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Fumatinic should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fumatinic while you are pregnant. Fumatinic is found in breast milk. If you are or will be breast-feeding while you use Fumatinic, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Fumatinic:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; flushing of the arms, face, or legs; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; severe or persistent stomach pain or cramping; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Fumatinic side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry, or bloody stools; drowsiness or dizziness; fainting; fast heartbeat; irritability; rapid breathing; seizures; severe or persistent nausea, vomiting, diarrhea, or stomach pain; sluggishness; vomit that looks like coffee grounds; weakness.

Proper storage of Fumatinic:

Store Fumatinic at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fumatinic out of the reach of children and away from pets.

General information:

• If you have any questions about Fumatinic, please talk with your doctor, pharmacist, or other health care provider.


• Fumatinic is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fumatinic. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Fumatinic resources

• Fumatinic Side Effects (in more detail)
• Fumatinic Use in Pregnancy & Breastfeeding
• Fumatinic Drug Interactions
• Fumatinic Support Group
• 0 Reviews for Fumatinic - Add your own review/rating

• Fumatinic Concise Consumer Information (Cerner Multum)


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Furocot

Generic Name: furosemide (Oral route)

fure-OH-se-mide

Oral route(Tablet)

Furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patient's needs .

Commonly used brand name(s)

In the U.S.

• Furocot


• Lasix

Available Dosage Forms:

• Tablet


• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Diuretic, Loop

Uses For Furocot

Furosemide belongs to a group of medicines called loop diuretics (also known as water pills). Furosemide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine.

Furosemide is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

This medicine is available only with your doctor's prescription.

Before Using Furocot

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of furosemide in children. However, premature babies are more likely to have unwanted effects on the kidney, which may require caution in patients receiving furosemide.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of furosemide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving furosemide.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amikacin


• Arsenic Trioxide


• Bepridil


• Chloral Hydrate


• Cisplatin


• Digitoxin


• Dofetilide


• Droperidol


• Ethacrynic Acid


• Gentamicin


• Kanamycin


• Ketanserin


• Levomethadyl


• Lithium


• Metolazone


• Neomycin


• Netilmicin


• Sotalol


• Streptomycin


• Tobramycin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alacepril


• Apazone


• Aspirin


• Benazepril


• Bromfenac


• Captopril


• Celecoxib


• Cephaloridine


• Cholestyramine


• Cilazapril


• Clofibrate


• Colestipol


• Cyclosporine


• Delapril


• Dibekacin


• Diclofenac


• Diflunisal


• Digoxin


• Enalaprilat


• Enalapril Maleate


• Etodolac


• Fenoprofen


• Fludrocortisone


• Flurbiprofen


• Fosinopril


• Germanium


• Ginseng


• Gossypol


• Ibuprofen


• Ibuprofen Lysine


• Imidapril


• Indomethacin


• Ketoprofen


• Ketorolac


• Licorice


• Lisinopril


• Magnesium Salicylate


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Moexipril


• Nabumetone


• Naproxen


• Nepafenac


• Oxaprozin


• Pancuronium


• Pentopril


• Perindopril


• Piroxicam


• Quinapril


• Ramipril


• Salicylic Acid


• Salsalate


• Spirapril


• Sulindac


• Temocapril


• Tolmetin


• Trandolapril


• Tubocurarine


• Vecuronium


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (not able to pass urine)—Should not be used in patients with this condition. .

• Anemia or


• Bladder problem with urinating or


• Dehydration or


• Diabetes mellitus or


• Gout or


• Hearing problems or


• Hyperuricemia (high uric acid in the blood) or


• Hypocalcemia (low calcium in the blood) or


• Hypochloremic alkalosis (low chlorine in the blood) or


• Hypokalemia (low potassium in the blood) or


• Hypomagnesemia (low magnesium in the blood) or


• Hyponatremia (low sodium in the blood) or


• Hypotension (low blood pressure) or


• Hypovolemia (low blood volume) or


• Liver disease, severe (e.g., cirrhosis) or


• Systemic lupus erythematosus (SLE) or


• Tinnitus (ringing in the ears) or


• Trouble urinating—Use with caution. May make these conditions worse.

• Hypoproteinemia (low protein in the blood) from a kidney problem or


• Radiocontrast nephropathy (kidney problem), history of—May cause side effects to become worse.

• Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of furosemide

This section provides information on the proper use of a number of products that contain furosemide. It may not be specific to Furocot. Please read with care.

Take this medicine exactly as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Many patients who have high blood pressure will not notice any symptoms of the condition. In fact, most patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

In addition to using this medicine, treatment of your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) or potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

This medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

If you are taking sucralfate (Carafate®), take this medicine 2 hours before or 2 hours after taking furosemide. It may keep furosemide from working properly.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (oral solution or tablets):
  
  • For edema:
    
    • Adults—At first, 20 to 80 milligrams (mg) once a day as a single dose or divided and given twice per day. Your doctor may adjust your dose as needed.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 2 milligrams (mg) per kilogram (kg) of body weight per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 6 mg per kg of body weight per day.
    
    
  
  
  • For high blood pressure:
    
    • Adults—At first, 40 milligrams (mg) two times per day. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Furocot

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood or urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant may cause your unborn baby to be bigger than normal. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause you or your child to lose more potassium from your body than normal (hypokalemia). This is more likely to occur if you have liver disease (e.g., cirrhosis), or if you are using this medicine together with steroids (cortisone-like medicines), adrenocorticotropic hormone (ACTH), large amounts of licorice, or laxatives for a long time. Tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea, and drink fluids to prevent getting dehydrated. Check with your doctor right away if you have one or more of these symptoms: dry mouth; increased thirst; muscle cramps; or nausea or vomiting.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

Stop using this medicine and check with your doctor right away if you or your child have a sudden decrease in hearing or loss of hearing. You may also have dizziness or ringing in the ears with the hearing problem. Tell your doctor if you have dizziness or lightheadedness; a feeling of constant movement of self or surroundings; or a sensation of spinning.

This medicine may cause an increase in blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen, hat, and protective clothing when you are outdoors. Avoid sunlamps and tanning beds.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

Furocot Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Chest pain


• chills


• cough or hoarseness


• fever


• general feeling of tiredness or weakness


• headache


• lower back or side pain


• painful or difficult urination


• shortness of breath


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen or painful glands


• tightness in the chest


• unusual bleeding or bruising


• unusual tiredness or weakness


• wheezing

Incidence not known

• Back or leg pains


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloating


• blood in the urine or stools


• blurred vision


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• changes in skin color, pain, tenderness, or swelling of the foot or leg


• clay-colored stools


• cloudy urine


• cold sweats


• confusion


• constipation


• continuing ringing or buzzing or other unexplained noise in the ears


• coughing up blood


• cracks in the skin


• darkened urine


• diarrhea


• difficulty breathing


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position


• dry mouth


• fast heartbeat


• flushed, dry skin


• fruit-like breath odor


• general body swelling


• greatly decreased frequency of urination or amount of urine


• hearing loss


• increased hunger


• increased thirst


• increased urination


• indigestion


• itching


• joint stiffness or swelling


• loss of appetite


• loss of heat from the body


• nausea or vomiting


• nosebleeds


• pain in the joints or muscles


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• pinpoint red spots on the skin


• red, irritated eyes


• red, swollen skin


• scaly skin


• severe abdominal or stomach pain


• skin rash


• stomach cramps


• sugar in the urine


• sweating


• swelling of the feet or lower legs


• troubled breathing with exertion


• unpleasant breath odor


• unusual weight loss


• vomiting of blood


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Decreased urination


• drowsiness


• increase in heart rate


• irregular heartbeat


• irritability


• mood changes


• muscle cramps


• numbness, tingling, pain, or weakness in the hands, feet, or lips


• rapid breathing


• seizures


• sunken eyes


• thirst


• trembling


• weak pulse


• weakness and heaviness of the legs


• wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Feeling of constant movement of self or surroundings


• hives or welts


• increased sensitivity of the skin to sunlight


• muscle spasm


• redness or other discoloration of the skin


• restlessness


• sensation of spinning


• severe sunburn


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Furocot side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Furocot resources

• Furocot Side Effects (in more detail)
• Furocot Use in Pregnancy & Breastfeeding
• Drug Images
• Furocot Drug Interactions
• Furocot Support Group
• 22 Reviews for Furocot - Add your own review/rating

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Fostril

Generic Name: sulfur topical (SULL fur)

Brand Names: Acnotex, Fostril, Liquimat Light, Liquimat Medium, Rezamid, Sulfo-Lo, Sulfoam, Sulforcin, Sulmasque, Sulpho-Lac, Sulpho-Lac Soap

What is Fostril (sulfur topical)?

Topical sulfur causes drying and peeling of the skin. This allows excess oil and dirt to be easily washed away.

Sulfur topical is used to treat acne.

Sulfur topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Fostril (sulfur topical)?

Do not use sulfur on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.

Avoid abrasive, harsh, or drying soaps and cleansers while using sulfur topical.

Who should not use Fostril (sulfur topical)?

Do not use sulfur topical on sunburned, windburned, dry, chapped, or irritated skin. It could make these conditions much worse. Also avoid using sulfur topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Do not use sulfur topical during treatment with other topical acne products unless otherwise directed with your doctor. The combination could lead to severe skin irritation.

It is not known whether sulfur topical will harm an unborn baby. Do not use sulfur topical without first talking to your doctor if you are pregnant. It is also not known whether sulfur passes into breast milk. Do not use sulfur topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Fostril (sulfur topical)?

Use sulfur topical exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after applying this medication.

Shake lotions well before using them. Clean and dry the area to which you will apply sulfur topical. Apply the medication to the affected area. When applying sulfur topical, avoid your eyes, the inside of your nose and mouth, your lips, and areas where the skin is broken to prevent excessive irritation. If you get medication in any of these areas, rinse it off with water.

Do not cover the affected area after applying sulfur topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by your body and could be harmful.

Sulfur topical is usually applied one to three times daily.

It may take several weeks or more to see the effects of this drug. Do not stop using sulfur topical if you do not see results immediately.

Apply sulfur topical less often if you experience excessive burning, dryness, or irritation.

Store sulfur topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and apply only your next regularly scheduled dose.

What happens if I overdose?

An overdose of sulfur topical is unlikely to occur. If you do suspect an overdose, or if sulfur topical has been ingested, call a poison control center or emergency room for advice.

What should I avoid while using Fostril (sulfur topical)?

Do not use sulfur topical on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.

Avoid using other topical products on the same area unless otherwise directed to do so by your doctor. They may interfere with the effects or absorption of sulfur topical.

Do not cover the area after applying sulfur topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by your body and could be harmful.

Avoid using harsh, abrasive or irritating cleansers, perfumes or cosmetics on the area you are treating.

Fostril (sulfur topical) side effects

Serious side effects are not likely to occur. Stop using sulfur topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

You may experience some burning, stinging, tingling, itching, redness, dryness, peeling, or irritation while you are using sulfur topical. If these side effects are excessive, apply sulfur topical less often.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fostril (sulfur topical)?

Do not use other topical preparations unless directed to do so by your doctor. They may interfere with your treatment or increase irritation to your skin.

Avoid using harsh, abrasive or irritating cleansers, perfumes, or cosmetics on the area you are treating.

Drugs other than those listed here may also interact with sulfur topical. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines.

More Fostril resources

• Fostril Side Effects (in more detail)
• Fostril Use in Pregnancy & Breastfeeding
• Fostril Drug Interactions
• Fostril Support Group
• 0 Reviews for Fostril - Add your own review/rating

• Sulfo-Lo Topical Advanced Consumer (Micromedex) - Includes Dosage Information

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Where can I get more information?

• Your pharmacist has additional information about sulfur topical written for health professionals that you may read.

See also: Fostril side effects (in more detail)

Fungizone

Generic Name: amphotericin B (am foe TER i sin)

Brand Names: Fungizone, Fungizone For Tissue Culture

What is Fungizone (amphotericin B)?

Amphotericin B is an antibiotic that fights fungal infections in the body.

Amphotericin B is used to treat serious, life-threatening fungal infections. It is not for use in treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina.

Amphotericin is usually given after other antifungal antibiotics have been tried without successful treatment of symptoms.

Amphotericin B may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Fungizone (amphotericin B)?

Do not receive this medication if you are allergic to any formulation of amphotericin B (Abelcet, AmBisome, Amphotec, or Fungizone).

Before you receive amphotericin B, tell your doctor if you are allergic to any drugs, or if you have kidney disease or heart disease.

Amphotericin B is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

The medicine must be given slowly through an IV infusion, and can take up to 6 hours to complete.

Amphotericin B may need to be given for up to several weeks or months, depending on the infection being treated.

Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if have a slow heartbeat, chest tightness, or trouble breathing.

What should I discuss with my health care provider before I receive Fungizone (amphotericin B)?

You should not receive this medication if you are allergic to any formulation of amphotericin B (Abelcet, AmBisome, Amphotec, or Fungizone).

Before you receive amphotericin B, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  kidney disease; or

  
  


• 
  

  heart disease.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive amphotericin B.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether amphotericin B passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is amphotericin B given?

Amphotericin B is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

The medicine must be given slowly through an IV infusion, and can take up to 6 hours to complete.

While you are receiving your amphotericin B infusion, your caregivers will check your blood pressure, pulse, temperature, and lung function about every 30 minutes.

To be sure this medication is not causing harmful effects, your blood cells, kidney function, and liver function may need to be tested on a regular basis. Amphotericin B can have long-lasting effects on your body. Do not miss any follow-up visits to your doctor for blood or urine tests.

Amphotericin B may need to be given for up to several weeks or months, depending on the infection being treated.

What happens if I miss a dose?

Since amphotericin B is usually given while you are in the hospital, it is not likely you will miss a dose of this medication.

If you are receiving amphotericin B in an outpatient clinic, call your doctor if you will miss an appointment for your amphotericin B injection.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include slow heart rate, and shallow breathing that slows or stops.

What should I avoid while receiving Fungizone (amphotericin B)?

Amphotericin B may lower the blood cells that help your body fight other infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Fungizone (amphotericin B) side effects

Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if you have a slow heartbeat, chest tightness, or trouble breathing. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your doctor at once if you have any of these serious side effects:

• 
  

  dry mouth, increased thirst, nausea, vomiting;

  
  


• 
  

  extreme drowsiness, restless feeling, confusion;

  
  


• 
  

  urinating more or less than usual, or not at all;

  
  


• 
  

  muscle pain or weakness, fast or uneven heart rate, feeling light-headed, fainting;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  pale skin, easy bruising or bleeding, unusual weakness; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  pain, swelling, or other irritation where the needle is placed;

  
  


• 
  

  mild nausea, vomiting, diarrhea, upset stomach, loss of appetite;

  
  


• 
  

  weight loss;

  
  


• 
  

  muscle or joint aches;

  
  


• 
  

  headache;

  
  


• 
  

  warmth, redness, or tingly feeling under your skin; or

  
  


• 
  

  skin itching or mild rash.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fungizone (amphotericin B)?

Before receiving amphotericin B, tell your doctor if you are using any of the following drugs:

• 
  

  flucytosine (Ancobon);

  
  


• 
  

  digoxin (digitalis, Lanoxin, Lanoxicaps);

  
  


• 
  

  pentamidine (Nebupent, Pentam);

  
  


• 
  

  tacrolimus (Prograf);

  
  


• 
  

  muscle relaxers;

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  antifungal antibiotics such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox);

  
  


• 
  

  antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);

  
  


• 
  

  antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or

  
  


• 
  

  cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid).

  
  

This list is not complete and there may be other drugs that can interact with amphotericin B. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Fungizone resources

• Fungizone Side Effects (in more detail)
• Fungizone Use in Pregnancy & Breastfeeding
• Fungizone Drug Interactions
• Fungizone Support Group
• 0 Reviews for Fungizone - Add your own review/rating

• Fungizone Prescribing Information (FDA)


• Fungizone MedFacts Consumer Leaflet (Wolters Kluwer)


• Fungizone Intravenous, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Amphotericin B Prescribing Information (FDA)


• Amphotericin B Monograph (AHFS DI)


• Amphotericin B Professional Patient Advice (Wolters Kluwer)

Compare Fungizone with other medications

• Aspergillosis, Aspergilloma
• Aspergillosis, Invasive
• Blastomycosis
• Candida Infections, Systemic
• Candida Urinary Tract Infection
• Coccidioidomycosis
• Coccidioidomycosis, Meningitis
• Cryptococcal Meningitis, Immunocompetent Host
• Cryptococcal Meningitis, Immunosuppressed Host
• Cryptococcosis
• Esophageal Candidiasis
• Fungal Endocarditis
• Fungal Infection Prophylaxis
• Histoplasmosis, Immunocompenent Host
• Histoplasmosis, Meningitis
• Leishmaniasis
• Oral Thrush
• Paracoccidioidomycosis
• Sporotrichosis

Where can I get more information?

• Your pharmacist can provide more information about amphotericin B.

See also: Fungizone side effects (in more detail)

Fosrenol

Pronunciation: LAN-tha-num KAR-bo-nate
Generic Name: Lanthanum Carbonate
Brand Name: Fosrenol

Fosrenol is used for:

Reducing blood phosphate levels in patients with end-stage kidney disease. It may also be used for other conditions as determined by your doctor.

Fosrenol is a phosphate binder. It works by blocking the absorption of phosphate, which reduces phosphate and calcium phosphate levels in the blood.

Do NOT use Fosrenol if:

• you are allergic to any ingredient in Fosrenol


• you have a blockage in your bowels (eg, ileus, impaction)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fosrenol:

Some medical conditions may interact with Fosrenol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have constipation, diabetes, or stomach or bowel problems (eg, an ulcer, ulcerative colitis, Crohn disease)


• if you have a history of colon cancer, or have had stomach or bowel surgery


• if you have dental problems that make chewing difficult. You may need to crush Fosrenol before taking it

Some MEDICINES MAY INTERACT with Fosrenol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Calcium channel blockers (eg, nifedipine) because the risk of serious stomach or bowel blockage may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fosrenol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fosrenol:

Use Fosrenol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Fosrenol by mouth with or immediately after meals.


• Chew or crush completely before swallowing. Do not swallow the tablet whole.


• Some medicines should not be taken at the same time as Fosrenol; their effectiveness may be decreased. If you are also taking ampicillin, an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril), an anti-malarial (eg, chloroquine), a quinolone antibiotic (eg, ciprofloxacin), a statin (eg, simvastatin), a tetracycline antibiotic (eg, doxycycline), or thyroid hormones (eg, levothyroxine), ask your doctor or pharmacist how to take them with Fosrenol.


• Medicines known to interact with antacids may interact with Fosrenol and should not be taken within 2 hours of taking Fosrenol.


• Take Fosrenol on a regular schedule to get the most benefit from it.


• Continue to take Fosrenol even if you feel well. Do not miss any doses.


• If you miss a dose of Fosrenol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fosrenol.

Important safety information:

• Do not take nonprescription antacids while taking Fosrenol without approval from your doctor.


• Tell your doctor or dentist that you take Fosrenol before you receive any medical or dental care, emergency care, or surgery.


• Fosrenol may interfere with stomach x-rays. Be sure your doctor and lab personnel know you are taking Fosrenol.


• Lab tests, including blood phosphate levels, may be performed while you use Fosrenol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Fosrenol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Fosrenol if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Fosrenol is found in breast milk. If you are or will be breast-feeding while you use Fosrenol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Fosrenol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent constipation, diarrhea, nausea, stomach cramping or pain, or vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Fosrenol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include headache; nausea; vomiting.

Proper storage of Fosrenol:

Store Fosrenol at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fosrenol out of the reach of children and away from pets.

General information:

• If you have any questions about Fosrenol, please talk with your doctor, pharmacist, or other health care provider.


• Fosrenol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fosrenol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Fosrenol resources

• Fosrenol Side Effects (in more detail)
• Fosrenol Use in Pregnancy & Breastfeeding
• Drug Images
• Fosrenol Drug Interactions
• Fosrenol Support Group
• 0 Reviews for Fosrenol - Add your own review/rating

• Fosrenol Prescribing Information (FDA)


• Fosrenol Consumer Overview


• Fosrenol Monograph (AHFS DI)


• Fosrenol Advanced Consumer (Micromedex) - Includes Dosage Information


• Lanthanum Carbonate Professional Patient Advice (Wolters Kluwer)

Compare Fosrenol with other medications

• Hyperphosphatemia of Renal Failure

Frovatriptan Succinate

Class: Selective Serotonin Agonists
VA Class: CN105
Chemical Name: (+)-(R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide butanedioate monohydrate
Molecular Formula: C₁₄H₁₇N₃O•H₂O
CAS Number: 158930-17-7
Brands: Frova

Introduction

Selective serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptor agonist (“triptan”).^{1 2}

Uses for Frovatriptan Succinate

Vascular Headaches

Acute treatment of migraine attacks with or without aura.^{1 4 5}

Not recommended for management of hemiplegic or basilar migraine or for prophylaxis of migraine.¹

Safety and efficacy not established for management of cluster headaches.¹

Frovatriptan Succinate Dosage and Administration

Administration

Oral Administration

Administer orally with fluids without regard to meals.¹

Dosage

Available as frovatriptan succinate; dosage is expressed in terms of frovatriptan.¹

Adults

Vascular Headaches

Migraine

Oral

2.5 mg as a single dose.¹ Higher dosages provide no additional benefit but may increase risk of adverse effects.^{1 2}

If headache recurs, additional doses may be administered at intervals of ≥2 hours, up to a maximum dosage of 7.5 mg in any 24-hour period.¹

If patient does not respond to first dose, additional doses are unlikely to provide benefit for the same headache.¹

Prescribing Limits

Adults

Vascular Headaches

Migraine

Oral

Maximum 7.5 mg in any 24-hour period.¹

Safety of treating an average of >4 headaches per 30-day period has not been established.¹

Special Populations

Hepatic Impairment

No dosage adjustment required in patients with mild to moderate hepatic impairment; not studied in patients with severe hepatic impairment.¹

Cautions for Frovatriptan Succinate

Contraindications

• 
  

  Known or suspected ischemic heart disease (e.g., angina pectoris, history of MI, documented silent ischemia).¹

  
  


• 
  

  Coronary artery vasospasm (e.g., Prinzmetal variant angina).¹

  
  


• 
  

  Other serious underlying cardiovascular disease (e.g., uncontrolled hypertension).¹

  
  


• 
  

  Cerebrovascular syndromes (e.g., stroke syndrome, TIAs).¹

  
  


• 
  

  Peripheral vascular ischemia (e.g., ischemic bowel disease).¹

  
  


• 
  

  Hemiplegic or basilar migraine.¹

  
  


• 
  

  Treatment within previous 24 hours with another 5-HT₁ receptor agaonist or an ergot alkaloid.¹ (See Specific Drugs under Interactions.)

  
  


• 
  

  Known hypersensitivity to frovatriptan or any ingredient in the formulation.¹

  
  

Warnings/Precautions

Warnings

Use only in patients in whom a clear diagnosis of migraine has been established.¹

If first migraine attack treated with frovatriptan fails to respond to the drug, reconsider diagnosis before administering frovatriptan to treat subsequent attacks.¹

Cardiac Effects

Risk of myocardial ischemia and/or infarction, coronary vasospasm, life-threatening cardiac rhythm disturbances, and death with use of 5-HT₁ receptor agonists.¹

Use not recommended in patients with known or suspected ischemic or vasospastic heart disease or in patients in whom unrecognized CAD is likely (e.g., postmenopausal women; men >40 years of age; patients with risk factors such as hypertension, hypercholesterolemia, smoking, obesity, diabetes, or family history of CAD) unless there is satisfactory evidence from prior cardiovascular evaluation that patient does not have CAD, ischemic heart disease, or other underlying cardiovascular disease.¹

Administer initial dose to patients with risk factors for CAD who have completed satisfactory cardiovascular evaluation under medical supervision (e.g., in clinician’s office, possibly followed by ECG) unless patient previously received the drug.¹

Periodic cardiovascular evaluation recommended in patients with risk factors for CAD if receiving intermittent long-term therapy.¹

Patients with symptoms suggestive of angina after receiving frovatriptan should be evaluated for presence of CAD or predisposition to Prinzmetal variant angina before receiving additional doses.¹

Cerebrovascular Events

Possible cerebral or subarachnoid hemorrhage, stroke, and other cerebrovascular events, sometimes fatal, with use of 5-HT₁ receptor agonists.¹

Risk of certain cerebrovascular events (e.g., stroke, hemorrhage, TIA) may be increased in patients with migraine.¹

Other Cardiovascular or Vasospastic Effects

Peripheral vascular ischemia and colonic ischemia with abdominal pain and bloody diarrhea reported with use of 5-HT₁ receptor agonists.¹ Further evaluation recommended if signs or symptoms of decreased arterial flow (e.g., ischemic colitis, Raynaud’s phenomenon) occur following administration.^{1 6 8}

Substantial increases in BP, including hypertensive crises, reported rarely with 5-HT₁ receptor agonists in patients with or without history of hypertension;^{1 6} transient increases in BP observed following administration of recommended dosage of frovatriptan (2.5 mg) in geriatric patients.¹

Increases in mean pulmonary artery pressure observed following administration of a 5-HT₁ receptor agonist to patients with suspected CAD who were undergoing cardiac catheterization.¹

Serotonin Syndrome

Potentially life-threatening serotonin syndrome reported during concurrent therapy with 5-HT₁ receptor agonists (“triptans”) and SSRIs or selective serotonin- and norepinephrine-reuptake inhibitors (SNRIs).^{1 11} Symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile BP, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination), and/or GI symptoms (e.g., nausea, vomiting, diarrhea).¹¹ (See Specific Drugs under Interactions.)

General Precautions

Ocular Effects

Possible accumulation of frovatriptan and/or its metabolites in melanin-rich tissues (e.g., eye) over time, resulting in potential toxicity in these tissues with extended use.¹

Specific Populations

Pregnancy

Category C.¹

Lactation

Distributed into milk in rats; not known whether distributed into milk in humans.¹ Caution advised if frovatriptan is used.¹

Pediatric Use

Safety and efficacy not established in children <18 years of age; use not recommended.¹

Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether they respond differently than younger adults.¹ (See Special Populations under Pharmacokinetics.)

Hepatic Impairment

Use with caution in patients with mild to moderate hepatic impairment.^{8 9} (See Special Populations under Pharmacokinetics.)

Not studied in patients with severe hepatic impairment.¹

Common Adverse Effects

Dizziness,¹ fatigue,¹ headache,¹ paresthesia,¹ flushing,¹ dry mouth,¹ hot or cold sensation,¹ skeletal pain,¹ dyspepsia,¹ chest pain,¹ somnolence,¹ nausea.¹

Interactions for Frovatriptan Succinate

Appears to be metabolized principally via CYP1A2.^{1 3 10}

Does not inhibit CYP1A2, 2C9, 2C19, 2D6, 2E1, or 3A4 or MAO isoenzymes in vitro; does not induce drug metabolizing enzymes.¹ Pharmacokinetic interaction with drugs metabolized by these isoenzymes unlikely.^{1 9}

Drugs Affecting Hepatic Microsomal Enzymes

Potential pharmacokinetic interaction (increased plasma frovatriptan concentrations) with concomitant use of CYP1A2 inhibitors; however, effects not considered clinically relevant.^{8 10}

Specific Drugs

Drug	Interaction	Comments
Antidepressants, SSRIs (e.g., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) or SNRIs (e.g., duloxetine, venlafaxine)	Potentially life-threatening serotonin syndrome1 11 Potential increase in blood frovatriptan concentrations with concomitant fluvoxamine administration10	Observe carefully if used concomitantly, particularly during treatment initiation, dosage increases, or when another serotonergic agent is initiated1 11 No dosage adjustment required if fluvoxamine is used concomitantly8 10
Ergot alkaloids (e.g., ergotamine, dihydroergotamine, methysergide)	Additive vasospastic effects1	Use within 24 hours contraindicated1
5-HT1 receptor agonists	Additive vasospastic effects1	Use within 24 hours contraindicated1
Oral contraceptives	Possible increased plasma concentrations of frovatriptan8 9	No dosage adjustment required8 9
Propranolol	Possible increased plasma concentrations of frovatriptan1 3 10	No dosage adjustment required8 10

Frovatriptan Succinate Pharmacokinetics

Absorption

Bioavailability

Incompletely absorbed from GI tract; absolute bioavailability of 20 and 30% in males and females, respectively.^{1 9}

Peak plasma concentrations attained approximately 2–4 hours after oral administration.^{1 9}

Food

Food does not affect bioavailability but may delay time to peak plasma concentration by 1 hour.¹

Distribution

Extent

Distributes into cellular fraction of blood, principally erythrocytes (approximately 60% reversibly bound).⁹

Animal studies indicate limited capacity to cross blood-brain barrier.⁹

Distributed into milk in rats; not known whether distributed into milk in humans.¹

Plasma Protein Binding

Approximately 15%.^{1 9}

Elimination

Metabolism

Appears to be metabolized principally via CYP1A2 to numerous metabolites, including desmethyl frovatriptan, which exhibits lower affinity for 5-HT_1B/1D receptors compared with frovatriptan.^{1 3}

Elimination Route

Excreted in urine (32%) and feces (62%) as unchanged drug and metabolites.¹

Half-life

Approximately 26 hours.^{1 9}

Special Populations

In patient with mild to moderate hepatic impairment, AUC is twofold higher than in healthy individuals; pharmacokinetics not studied in patients with severe hepatic impairment.¹

In geriatric patients, AUC is 1.5- to 2-fold higher than in younger adults; half-life and time to peak plasma concentrations unchanged.¹

Stability

Storage

Oral

Tablets

25°C (may be exposed to 15–30°C).¹ Protect from moisture and light.¹

ActionsActions

• 
  

  Binds with high affinity to 5-HT_1B and 5-HT_1D receptors.¹

  
  


• 
  

  Structurally distinct from, but pharmacologically related to, other selective 5-HT_1B/1D receptor agonists (e.g., almotriptan, eletriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan).^{2 7 8}

  
  


• 
  

  Precise mechanism of action not established;⁶ may ameliorate migraine through selective constriction of certain intracranial blood vessels, inhibition of neuropeptide release, and reduced transmission in trigeminal pain pathway.^{1 2}

  
  

Advice to Patients

• 
  

  Importance of immediately informing clinician if tightness, pain, pressure, or heaviness in chest, throat, jaw, or neck occurs¹ and of not taking frovatriptan again until evaluated by clinician.⁸

  
  


• 
  

  Importance of taking frovatriptan exactly as prescribed.¹

  
  


• 
  

  Importance of providing patient a copy of manufacturer’s patient information.¹

  
  


• 
  

  Risk of dizziness or fatigue; importance of exercising caution when driving or operating machinery.¹

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and herbal supplements, as well as any concomitant illnesses (e.g., cardiovascular disease).¹

  
  


• 
  

  Importance of informing patients of risk of serotonin syndrome with concurrent use of frovatriptan and an SSRI or SNRI.^{1 11} Importance of seeking immediate medical attention if symptoms of serotonin syndrome develop.¹¹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing patients of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Frovatriptan Succinate

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Tablets, film-coated	2.5 mg (of frovatriptan)	Frova	Endo

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Frova 2.5MG Tablets (ENDO PHARMACEUTICALS): 9/$241.99 or 27/$699.93

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions May 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Endo Pharmaceuticals Inc. Frova (frovatriptan succinate) tablets prescribing information. Chadds Ford, PA; 2006 Jun.

2. Tfelt-Hansen P, De Vries P, Saxena PR. Triptans in migraine: a comparative review of pharmacology, pharmacokinetics, and efficacy. Drugs. 2000; 60:1259-87. [PubMed 11152011]

3. Jhee SS, Shiovitz T, Crawford AW et al. Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review. Clin Pharmacokinet. 2001; 40:189-205. [PubMed 11327198]

4. Matchar DB, Young WB, Rosenberg JH et al. Evidence-based guidelines for migraine headache in the primary care setting: pharmacological management of acute attacks. From American Academy of Neurology web site ().

5. Silberstein SD, for the US Headache Consortium. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 2000; 55:754-63. [IDIS 453389] [PubMed 10993991]

6. GlaxoWellcome. Amerge (naratriptan hydrochloride) tablets prescribing information. Research Triangle Park, NC; 1999 Nov.

7. Deleu D, Hanssens Y. Current and emerging second-generation triptans in acute migraine therapy: a comparative review. J Clin Pharmacol. 2000; 40:687-700. [IDIS 449430] [PubMed 10883409]

8. Elan Pharmaceuticals, South San Francisco, CA: Personal communication.

9. Buchan P, Keywood C, Wade A et al. Clinical pharmacokinetics of frovatriptan. Headache. 2002; 42(Suppl 2):S54-62.

10. Buchan P, Wade A, Ward C et al. Frovatriptan: a review of drug-drug interactions. Headache. 2002; 42(Suppl 2):S63-73.

11. Food and Drug Administration. Public health advisory: combined use of 5-hydroxytryptamine receptor agonists (triptans), selective serotonin reuptake inhibitors (SSRIs) or selective serotonin/norepinephirne reuptake inhibitors (SNRIs) may result in life-threatening serotonin syndrome. Rockville, MD; 2006 Jul 19. From the FDA website: ( and ).

More Frovatriptan Succinate resources

• Frovatriptan Succinate Side Effects (in more detail)
• Frovatriptan Succinate Dosage
• Frovatriptan Succinate Use in Pregnancy & Breastfeeding
• Frovatriptan Succinate Drug Interactions
• Frovatriptan Succinate Support Group
• 16 Reviews for Frovatriptan Succinate - Add your own review/rating

Compare Frovatriptan Succinate with other medications

• Migraine

Frova

Generic Name: frovatriptan (FRO va trip tin)

Brand Names: Frova

What is Frova (frovatriptan)?

Frovatriptan is a headache medicine that narrows blood vessels around the brain. Frovatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Frovatriptan is used to treat migraine headaches. Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Frovatriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medication only if your condition has been confirmed by a doctor as migraine headaches.

Frovatriptan may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Frova (frovatriptan)?

You should not take this medication if you are allergic to frovatriptan, if you have any history of heart disease, or if you have coronary heart disease, angina, blood circulation problems, lack of blood supply to the heart, uncontrolled high blood pressure, ischemic bowel disease, a history of a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not take frovatriptan within 24 hours before or after using another migraine headache medicine, including almotriptan (Axert), eletriptan (Relpax), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Treximet), zolmitriptan (Zomig), or ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

Before taking frovatriptan, tell your doctor if you have liver or kidney disease, high blood pressure, a heart rhythm disorder, or coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

Also tell your doctor if you are also taking an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.

What should I discuss with my healthcare provider before using Frova (frovatriptan)?

You should not use this medication if you are allergic to frovatriptan, or if you have:

• 
  

  coronary heart disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;

  
  


• 
  

  a history of heart disease, heart attack, or stroke, including "mini-stroke";

  
  


• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  ischemic bowel disease; or

  
  


• 
  

  a headache that seems different from your usual migraine headaches.

  
  

To make sure you can safely take frovatriptan, tell your doctor if you have any of these other conditions:

• liver disease;


• kidney disease;


• 
  

  high blood pressure, a heart rhythm disorder; or

  
  


• 
  

  coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

  
  

FDA pregnancy category C. It is not known whether frovatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether frovatriptan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to anyone under 18 years old.

How should I use Frova (frovatriptan)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Overuse of migraine headache medicine can actually make your headaches worse.

Take frovatriptan as soon as you notice headache symptoms, or after an attack has already begun.

Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.

Take one frovatriptan tablet whole with a full glass of water.

After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than three (3) frovatriptan tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Contact your doctor if you have more than four headaches in one month (30 days).

If you use frovatriptan long-term, your doctor may want to check your heart function using an electrocardiograph or ECG (sometimes called an EKG), a machine that measures electrical activity of the heart. This will help your doctor determine if it is still safe for you to use this medication. Do not miss any scheduled visits to your doctor.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since frovatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using frovatriptan.

After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Frova (frovatriptan)?

Do not take frovatriptan within 24 hours before or after using another migraine headache medicine, including:

• 
  

  almotriptan (Axert), eletriptan (Relpax), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex, Treximet), or zolmitriptan (Zomig); or

  
  


• 
  

  ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

  
  

Frovatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Frova (frovatriptan) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using frovatriptan and call your doctor at once if you have a serious side effect such as:

• 
  

  feeling of pain or tightness in your jaw, neck, or throat;

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden severe headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  sudden and severe stomach pain and bloody diarrhea;

  
  


• 
  

  numbness or tingling and a pale or blue-colored appearance in your fingers or toes; or

  
  


• 
  

  (if you are also taking an antidepressant) -- agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

  
  

Less serious side effects may include:

• 
  

  mild headache (not a migraine);

  
  


• 
  

  feeling too warm or too cold;

  
  


• 
  

  dry mouth, upset stomach;

  
  


• 
  

  bone or joint pain;

  
  


• 
  

  pressure or heavy feeling in any part of your body;

  
  


• 
  

  dizziness, drowsiness, tired feeling; or

  
  


• 
  

  warmth, redness, or mild tingling under your skin.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Frova (frovatriptan)?

Tell your doctor about all other medicines you use, especially:

• 
  

  propranolol (Inderal, InnoPran);

  
  


• 
  

  an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

  
  

This list is not complete and other drugs may interact with frovatriptan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Frova resources

• Frova Side Effects (in more detail)
• Frova Dosage
• Frova Use in Pregnancy & Breastfeeding
• Drug Images
• Frova Drug Interactions
• Frova Support Group
• 15 Reviews for Frova - Add your own review/rating

• Frova Prescribing Information (FDA)


• Frova Monograph (AHFS DI)


• Frova Advanced Consumer (Micromedex) - Includes Dosage Information


• Frova MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Frova with other medications

• Migraine

Where can I get more information?

• Your pharmacist can provide more information about frovatriptan.

See also: Frova side effects (in more detail)